Physics 177

Principles of Molecular Biophysics
Spring 2010

Professor: Carlos Bustamante
GSI: Gheorghe Chistol

Lectures:
Tu/Th 8-9:30am, 241 Cory Hall

Discussions:
Thu 1-2pm, 70 Evans
Wed 4-5pm, 51 Evans

Carlos's Office Hrs: Tue 9:30-10:30am, Stanley Hall 608A (+ by appt)
Ghe's Office Hrs: Wed 5-6pm, Stanley Hall 625 (+ by appt)

Homework
PS0: Thermodynamics, Not Graded
PS0 Solutions

PS1: Chain Statistics (due Feb 12 @ 7pm) [reading suggestions]
PS1 Solutions
Histogram

PS2: Helix-Coil Transition (due Feb 26 @ 5pm)
PS2 Solutons
Histogram

PS3: Fluorescence (due Apr 9 @ 5pm)

PS4: Single Molecule Methods (due Apr 30 @ 5pm)

Lecture Slides
Lecture 1 [pdf] (19 Jan 2010, Course Overview, Intro to Thermodynamics)
Lecture 2 [pdf] (21 Jan 2010, Thermodynamics Concepts, Acid-Base Equilibrium)
Lecture 3 [pdf] (25 Jan 2010, Intro to Proteins)
Lecture 4 [pdf] (28 Jan 2010, Proteins: Secondary, Tertiary, Quaternary Structure)
Lecture 5 [pdf] (02 Feb 2010, DNA Helix, Intro to Polymer Chains; warning: Large File)
Lecture 6 [pdf] (04 Feb 2010, Chain Statistics, Continued; warning: Large File)
Lecture 7 [pdf] (16 Feb 2010, Helix-Coil Transition)
Lecture 8 [pdf] (18 Feb 2010, Polyelectrolite Theory)
Lecture 9 [pdf] (23 Feb 2010, Intro to Protein Folding)
Lecture 10 [pdf] (25 Feb 2010, Protein Folding, Prof Marqusee)
Lecture 11 [pdf] (03 Mar 2010, Intro to RNA, Prof Tinoco)
Lecture 12 [pdf] (05 Mar 2010, Intro to XRay Crystallography, Prof Berger)
Fluorescence: Intro [pdf] (warning, 13.5Mb)
Fluorescence: Polarization [pdf] (warning, 8Mb)
Molecular Structures via NMR [pdf]
Intro to Atomic Force Microscopy [pdf] (warning, 12Mb)
Intro to Single Molecule Manipulation [pdf]
Intro to Optical Tweezers [pdf]
Extra Reading Materials[pdf]

Discussion Session Notes
Calculating the Isoelectric Point [pdf] (27/29 Jan 2010)
Chain Statistics [pdf] (03/04 Feb 2010)

Last updated on Mar 17 2010